Role of food-derived antioxidant agents against acetaminophen-induced hepatotoxicity
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چکیده
منابع مشابه
Hepatoprotective and Antioxidant Effect of Pavonia Zeylanica against Acetaminophen Induced Hepatotoxicity in Rats
The objective of the study was to investigate the methanol extract of Pavonia zeylanica (MEPZ) against acetaminophen induced hepatotoxicity and antioxidant activity in Wistar albino rats.The methanol extract of pavonia zeylanica (200, and 400 mg/kg body weight) was administered orally to two groups of rats (six animals per group) in order to evaluate the protective effect of the extract in rats...
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Acetaminophen (APAP) overdose is one of the most common causes of acute liver failure. The study aimed to investigate the protective effect of carnosic acid (CA) on APAP-induced acute hepatotoxicity and its underlying mechanism in mice. To induce hepatotoxicity, APAP solution (400 mg/kg) was administered into mice by intraperitoneal injection. Histological analysis revealed that CA treatment si...
متن کاملAcetaminophen-induced hepatotoxicity.
The analgesic acetaminophen causes a potentially fatal, hepatic centrilobular necrosis when taken in overdose. The initial phases of toxicity were described in Dr. Gillette's laboratory in the 1970s. These findings indicated that acetaminophen was metabolically activated by cytochrome P450 enzymes to a reactive metabolite that depleted glutathione (GSH) and covalently bound to protein. It was s...
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ژورنال
عنوان ژورنال: Pharmaceutical Biology
سال: 2016
ISSN: 1388-0209,1744-5116
DOI: 10.3109/13880209.2016.1150302